Basophilic Response in Patients with Persistent Symptoms Attributed to Lyme Borreliosis Treated with Hydrolysed Arabinoxylan Rice Bran
Basant K. Puri, Gary S. Lee, Georgia Tuckey, Lisa Wyness, Reine Corley, Lucy Monaghan and Sari J. Arminen2025 Background and Objectives: MGN-3/Biobran (BRM4, Lentin Plus or Ribraxx) is a natural, rice bran-derived arabinoxylan immunoceutical that modulates the adaptive immune response to viral infections. In response to bacterial infections, basophils act as “first responders” and are […]
Nanoparticle Enhanced. The Protective Effects of MGN-3 BioBran Against Ehrlich Ascites Carcinoma-Induced Toxicity in the Liver, Kidneys and Spleen of Mice
Zeinab A Mostafa, Mai Alaa El-Dein, Mamdooh Ghoneum and Nariman K. Badr El-Din2025 Background: Nanoparticle-enabled targeted drug delivery has proven effective in cancer treatment due to its ability to cross biological barriers, achieve therapeutic concentrations within tumors, and minimize adverse effects on surrounding healthy tissues. MGN-3/Biobran is a widely recognized natural compound known for its […]
Biobran/MGN-3: A Promising Natural Strategy for Mitigating Kidney Damage and Immune Modulation During Etoposide Therapy
Ali M. Eldib, Haytham M. Abdellatif, Osman Suliman, Faris M. Elmahdi, Ibrahim H. Babikir, Shimaa B. Hemdan, Reem M. Emam, Mohamed S. El-Gerbed, Mamdooh H Ghoneum, Attalla F. El-kott, Sara M. Altom2025 Although chemotherapy is one of the pillars in cancer treatment, its side effects have extremely harmful impacts on many of the body’s organs. […]
Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms
Soo Liang Ooi , Peter S. Micalos, Jeanman Kim and Sok Cheon Pak2024 Context: Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties. Objective: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment. Methods: This secondary analysis of a scoping review includes […]
Biobran/MGN-3, an Arabinoxylan Rice Bran, Exerts Anti-COVID-19 Effects and Boosts Immunity in Human Subjects
Sudhanshu Agrawal, Anshu Agrawal and Mamdooh Ghoneum2024 Corona Virus Disease 19 (COVID-19) has been a major pandemic impacting a huge population worldwide, and it continues to present serious health threats, necessitating the development of novel protective nutraceuticals. Biobran/MGN-3, an arabinoxylan rice bran, is a potent immunomodulator for both humans and animals that has recently been […]
Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study
Mamdooh Ghoneum, Shaymaa Abdulmalek and Hewida H. Fadel2023 Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), poses a serious global public health threat for which there is currently no satisfactory treatment. This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2. Biobran is an arabinoxylan rice bran that […]
Enhancing effect of streptozotocin-induced insulin deficit on antitumor innate immune defense in rats
Hajto Tibor, Péczely László, Kuzma Monika, Hormay Edina, Ollmann Tamás, Jaksó Pál, Baranyai Lilla and Karádi Zoltán2022 Background: There are conflicting data about the relationship between diabetes mellitus and cancer risk in that growing evidence suggest a possible role of endogenous elevated insulin level which is often found in Non-Insulin-Dependent-Diabetes-Mellitus or an exogenous hyperinsulinemia observed […]
Dieatary Supplementation with BioBran-MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses s in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial
Ahmed F. Elsaid , Sudhanshu Agrawal , Anshu Agrawal and Mamdooh Ghoneum2021 Abstract: Influenza-like illness (ILI) remains a major cause of severe mortality and morbidity in the elderly. Aging is associated with a decreased ability to sense pathogens and mount effective innate and adaptive immune responses, thus mandating the development of protective nutraceuticals. Biobran/MGN-3, an […]
Clinical Cancer Strategy (Clinical Review)
Serge Jurasunas2021 This clinical cancer strategy incorporates advancements in cancer treatment based on a multi-approach to the disease that includes targeting apoptosis, immune cell activation, angiogenesis, restoration of cellular respiration, inhibition of inflammatory mediators, not mentioning some secondary factors such as intoxication, disturbed microbiome, and nervous disorders. I believe that a real breakthrough in cancer […]
Rice bran arabinoxylan compound and quality of life of cancer patients (RBAC – QoL): Study protocol for a randomized pilot feasibility trial
Soo Liang Ooi, Sok Cheon Pak, Peter S. Micalos , Emily Schupfer, Rob Zielinski, Thomas Jeffries, Garth Harris, Terry Golombick, David McKinnon2020 Introduction : Rice bran arabinoxylan com pound (RBAC) is a nutraceutical for enhancing a depleted immune system during and after cancer treatment. This pilot feasibility trial aims to evaluate the effects of RBAC […]