Arabinoxylan Rice Bran (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-year Randomized Clinical Trial
Mai Hong Bang, Tran Van Piep, Nguyen Tien Thinh, Le Huu Song, Trinh Tuan Dung, Le Van Truong, Le Van Don, Thai Doan Ky, Deyu Pan, Magda Shaheen and Mamdooh Ghoneum2010 Background and Aims: This study examined the efficacy of arabinoxylan rice bran (MGN-3) in conjunction with an interventional therapy (IT) for the treatment of […]
Biobran-augmented maturation of human monocyte derived dendritic cells
D.Cholujova, J.Jakubikova, J.Sedlak2009 BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). lmmature DC (iDC) derived from plastic-adhered, lL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix l (CMMl; TNF-alfa, lL-1[5 and 1L-6) or CMM2 (LPS and […]
In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcinoma-Bearing Mice
N. El-Din, E. Noaman and M. Ghoneum2008 This study was undertaken to investigate the in vivo anti-tumor activity of MGN-3/Biobran, a modified arabinoxylan rice bran. Swiss albino mice were inoculated intramuscularly in the right thigh with Ehrlich ascites carcinoma (EAC) cells. On Day 8, mice bearing a solid Ehrlich carcinoma (SEC) tumor were treated with […]
MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin
S. Gollapudi and M. Ghoneum2008 MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi S. MGN-3 sen sitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett […]
Modulation of the anticancer immunity by natural agents: inhibition of T regulatory lymphocyte generation by arabinoxylan in patients with locally limited or metastatic solid tumors
P. Lissoni, G. Messina, F. Brivio, L. Fumagalli, L. Vigore, F. Rovelli, L. Maruelli, M. Miceli, P. Marchiori, G. Porro, M. Held, G. di Fede, T Uchiyamada2008 In the last years, several immunomodulating antitumor agents have demonstrated in the nature, particularly from Aloe plant and rice bran. However, the major problem concerning the natural antitumor agents […]
Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Intracellular Killing of Microbes by Human Phagocytic Cells In Vitro
M. Ghoneum, M. Matsuura and S. Gollapudi2008 Phagocytic cells, comprised of neutrophils and moncytyes/macrophages, play a key role in the innate immune response to infection. Our earlier study demonstrated that arabinoxylan rice bran (MGN-3/Biobran) activates murine peritoneal macrophage and macrophage cell lines. ln this study, we investigated whether MGN-3 can upregulate the phagocytic activity of […]
Yeast Therapy For the Treatment of Cancer and its Enhancement by MGN-3/Biobran, an Arabinoxylan Rice Bran
M. Ghoneum, J. Brown and S. Gollapudi2007 Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative killing that involves both cancer cells and many normal cells. It is therefore […]
Metastatic Hemangiopericytoma of the Skin Treated with Wide Local Excision and MGN-3
J. Markus, A. Miller, M. Smith, I. Orengo2006 Abstract: This case report describes an uncommon tumor treated with an unproven medication found by the patient during an Internet search. MGN-3 is an arabinoxylane derived from rice bran that has been enzymatically modified by an extract of the mushroom Hypbomycetes mycelicz. ln vivo murine studies have […]
Apoptosis of Breast Cancer MCF-7 Cells In Vitro is Induced Specifically by Yeast and Not by Fungal Myceli
M. Ghoneum and S. Gollapudi2006 lt was recently demonstrated that breast cancer cell lines undergo apoptosis following phagocytosis of S. cerevisiae. The present study was undertaken to determine whether other strains of fungi also induce apoptosis in cancer cells. Eight strains of yeast: C. albicans, C. krusei, C. glabrata, C. kefyr, C. neoformans, Y lipolytica, […]
Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells peer-reviewed
M. Ghoneum and S. Gollapudi2005 We have recently demonstrated that breast cancer cell (BCC) lines undergo apoptosis following phagocytosis of S. cerevisiae. Arabinoxylan rice bran extract (MGN-3/Biobran) has been shown to enhance this effect. Since previous data were obtained using cells in suspension, the present study was undertaken to examine monolayer BCC that more closely […]