Effect of the purified filtrate of Bacillus subtilis var. natto culture on the lectin-like oxidized low-density lipoprotein receptor index

  • Kazutoshi Kaketani
  • (edited by Chris Gutch PhD.)
  • 2021

The lectin-like oxidized low-density lipoprotein receptor index (LOX index) is a biomarker for monitoring the progression of arteriosclerosis, and is calculated by multiplying the lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) ligands containing apolipoprotein B (LAB) and soluble LOX-1 (sLOX-1).

We carried out a pilot study to evaluate the effect of the purified filtrate of Bacillus subtilis var. natto culture (NKCP), which is a functional food derived from “natto” (a traditional Japanese foodstuff of fermented soybeans), on the LOX index of patients with a high value. The LOX index was lower in more than half of the patients, although the results did not clearly show that NKCP lowered the LOX index. However, the lowering effect of NKCP on the LOX index was mainly due to the reduced sLOX-1. Therefore, NKCP may have anti-inflammatory effects.

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